tag:blogger.com,1999:blog-69605032024-03-05T14:37:01.479-06:00On-line Journal of Genetics and GenealogyThe On-line Journal of Genetics and Genealogy will highlight the connections between the science of Y and X chromosome, mitochondrial, and autosomal DNA analysis and genealogy. Reference will be made to scientific and genealogy articles which complement each other and advance the study of recent family history and ancient human migrations.Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.comBlogger325125tag:blogger.com,1999:blog-6960503.post-63527878216951192192023-08-15T10:21:00.001-05:002023-08-15T10:21:35.221-05:00Adoption Law Change in MinnesotaFrom Eastman Online:<a href="https://eogn.com/page-18080/13239624" rel="nofollow">Minnesota Unseals Original Adoption Records Starting July 2024 </a>
<p>The following is an announcement issued by the State of Minnesota:
<p>
Birth Records and Adoption
<p><blockquote>
Law change: Adoptee access to original birth records
Beginning July 1, 2024, adopted people born in Minnesota who are 18 or older will be able to request their original birth records. Birth parents named
on an original birth record may submit a contact preference form (see information below) to indicate their preference for contact by the adopted person.</blockquote>
</p>
<p> <a href="https://eogn.com/page-18080/13239624" rel="nofollow">Continues here</a></p>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-22645451661691586202023-04-25T12:07:00.004-05:002023-04-25T12:07:53.862-05:00Roots Tech DNA Day sessions<p>These will be recorded and on the Internet.
<p><center><a href="https://www.familysearch.org/en/blog/april-25-is-dna-day#.ZEDiZv6Sk4o.facebook" rel="nofollow"><b>Celebrate DNA Day</b></a></center>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-46864966863357179802022-10-04T09:57:00.002-05:002022-10-04T09:57:41.388-05:00MyHeritage has a new way to sort shared DNA matches<div class="separator" style="clear: both;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhlMHtJtarpldIxxQ4oDccRmxJji1j-MAN2glpeywKjCwMLsdbS7NoCpt22JXVaUS6sOqwqa2cV7S4JiHgpy0Y7IwwgdGWGSjDRwz06oXO431d246by_I5z2GqlotqOZB9yqH3kjW7Gt5BVIK_al26ojIgGJZC_UBpbfFguR1XN51lyf_QMqvs/s605/SortMH.JPG" style="display: block; padding: 1em 0; text-align: center; "><img alt="" border="0" width="320" data-original-height="349" data-original-width="605" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhlMHtJtarpldIxxQ4oDccRmxJji1j-MAN2glpeywKjCwMLsdbS7NoCpt22JXVaUS6sOqwqa2cV7S4JiHgpy0Y7IwwgdGWGSjDRwz06oXO431d246by_I5z2GqlotqOZB9yqH3kjW7Gt5BVIK_al26ojIgGJZC_UBpbfFguR1XN51lyf_QMqvs/s320/SortMH.JPG"/></a></div>
<p>We’re happy to announce the addition of sorting abilities for Shared DNA Matches. It’s one of several new improvements we’re making to DNA Matches on MyHeritage in the coming weeks.
<p>Shared DNA Matches are a valuable tool for users interested in figuring out how they’re related to a specific DNA match. The new sorting functionality enables you to sort your Shared DNA Matches based on the proximity of their relationship to you or to the DNA Match you’re reviewing, and gain new insights.
<p>Sorting of Shared DNA Matches is unique to MyHeritage, and this new addition has already received praise from experts in the genealogy community. Diahan Southard of Your DNA Guide says, “SWEET!! This is one of my requested features and will make a big difference”, and Janna Helshtein from DNA at Eye Level says, “This is an amazing feature, I LOVE LOVE LOVE it!”
See this link: <a href="https://blog.myheritage.com/2022/10/new-sorting-for-shared-dna-matches/" rel="nofollow">New sorting for shared DNA matches</a>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-46048107269971572242022-08-31T12:28:00.001-05:002022-08-31T12:28:27.680-05:00Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluatedThis article reviews Principal Component Analysis (PCA), as applied to populaation genetics, <a href="https://www.nature.com/articles/s41598-022-14395-4#Sec22" rel="nofollow"><b>Principal Component Analyses (PCA)-based findings in population genetic studies are highly biased and must be reevaluated. It also suggests other methods that may provide more valid results.</b></a>
<p>Abstract<br><br>
Principal Component Analysis (PCA) is a multivariate analysis that reduces the complexity of datasets while preserving data covariance. The outcome can be visualized on colorful scatterplots, ideally with only a minimal loss of information. PCA applications, implemented in well-cited packages like EIGENSOFT and PLINK, are extensively used as the foremost analyses in population genetics and related fields (e.g., animal and plant or medical genetics). PCA outcomes are used to shape study design, identify, and characterize individuals and populations, and draw historical and ethnobiological conclusions on origins, evolution, dispersion, and relatedness. The replicability crisis in science has prompted us to evaluate whether PCA results are reliable, robust, and replicable. We analyzed twelve common test cases using an intuitive color-based model alongside human population data. We demonstrate that PCA results can be artifacts of the data and can be easily manipulated to generate desired outcomes. PCA adjustment also yielded unfavorable outcomes in association studies. PCA results may not be reliable, robust, or replicable as the field assumes. Our findings raise concerns about the validity of results reported in the population genetics literature and related fields that place a disproportionate reliance upon PCA outcomes and the insights derived from them. We conclude that PCA may have a biasing role in genetic investigations and that 32,000-216,000 genetic studies should be reevaluated. An alternative mixed-admixture population genetic model is discussed.</p>
<p>Moving beyond PCA<br><br>
As an alternative to PCA, we briefly note the advantages of a supervised machine-like model implemented in tools like the Geographic Population Structure (GPS)85 and Pairwise Matcher (PaM)57. In this model, gene pools are simulated from a collection of geographically localized populations. The ancestry of the tested individuals is next estimated in relation to these gene pools. In this model, all individuals are represented as the proportion of gene pools. Their results do not change when samples are added or removed in the second part of the analysis. Population groups are bounded within the gene pools, and inclusion in these groups can be evaluated. This model was shown to be reliable, replicable, and accurate for many of the applications discussed here, including biogeography85, population structure modeling106, ancestry inference107, paleogenomic modeling108, forensics86, and cohort matching57. An evaluation of other tools that may be useful to infer the population structure and their limitations can be found elsewhere37,109.</p>
Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-66673129584697555002021-08-17T17:56:00.004-05:002021-08-17T17:56:43.394-05:00Born and adopted in Connecticut before 1983? You can get your original birth certificateFrom The Bristol Pres via EOGN.org:
<a href="http://www.bristolpress.com/BP-Bristol+News/394423/people-born-and-adopted-in-connecticut-can-obtain-their-own-birth-records-for-first-time-in-decades" rel="nofollow">Born and adopted in Connecticut before 1983? You can get your original birth certificate</a>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-76367242195835171532020-11-25T09:46:00.001-06:002021-08-17T17:58:45.659-05:00New Zealand Law Commission report on genetic genealogy, DNA, and the Police<p>New Zealand was the second national jurisdiction to institute legislation on the Police use of DNA. Recently the NZ Law Commission made a new report with 193 recommendations on DNA use and genetic genealogy for Police purposes. The Report recommends that more attention be given to Maori, Treaty of Watangi, and human rights issues. The report is available at <a href="https://www.lawcom.govt.nz/our-projects/use-dna-criminal-investigations?id=1627">The Use of DNA in Criminal Investigations</a>.
<p>This issue has arisen within the genetic genealogy community due to the rise of forensic, or investigative genetic genealogy, in regard to <a href="https://www.gedmatch.com/">Gedmatch</a> and <a href="https://ftdna.com/">Family Tree DNA</a>. At Gedmatch one has to <a href="www.gedmatch.com/tos.htm">opt-in to allow law enforecement use</a> (see, "Public + opt-in" and "Public + opt-out") and at FTDNA one has to <a href="https://www.familytreedna.com/legal/law-enforcement-guide">opt-out to deny law enforcement use</a> of your genetic data in criminal investigations.
<p>It will be interesting to see if the NZ Law Commission Report has any effects within the broader genetic genealogy community and the <a href="https://gdpr-info.eu/">GDPR</a> and <a href="https://leginfo.legislature.ca.gov/faces/billTextClient.xhtml?bill_id=201720180AB375">CCPA</a> legal regimes.Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com2tag:blogger.com,1999:blog-6960503.post-46595088735357196082020-07-20T21:54:00.000-05:002020-07-20T21:54:18.230-05:00Ancestry decision to remove matches below 8 cM will harm African American and Native American descendants<p>Sometime in August, Ancestry intends to remove matches in the 6 to 7.9 cM range from DNA match lists. This will cause problems for African American genealogists since using those matches, even if 50% are false matches, is often the only way for African American genealogists to find possible connections that predate the end of slavery and the 1870 census. You can preserve these matches by saving a note or adding them to a dot group or by messaging them. Doing so will take time but it is possible. One way is to search by custom centimorgan size and then to search for common ancestors and add a dot group for each. I have been doing this as group CA67.
<p>The same argument can be made for people with documented genealogical ancestry from Native Americans which predates 1870. This range of matches needs to be preserved and continue to be available to anyone who wants to see them.
<p>See this blog post from Roberta Estes, for a more in-depth analysis of this proposed change: <a href="https://dna-explained.com/2020/07/19/plea-to-ancestry-rethink-match-purge-due-to-deleterious-effect-on-african-american-genealogists">Plea to Ancestry – Rethink Match Purge Due to Deleterious Effect on African American Genealogists</a>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com1tag:blogger.com,1999:blog-6960503.post-17746247796365865062020-04-26T13:46:00.000-05:002020-04-26T14:26:45.225-05:00DNA Day SalesApril 25th is <a href="https://www.genome.gov/dna-day">National DNA Day</a> and the genetic genealogy companies had or are having sales on DNA tests.<br />
<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhIeVl-LgGvBuFPFtI7LYCBLu7XrIUvMD-tLvqQVDLmWUmHEJmcpaeX14HMrXNvAeAek2h6QaZjK1ERezrUqMaeIdGBb9XjIQ-eCcRjTJC6OzkxpIzYQ2zIVZ3_pnPwrhh5HlrTWw/s1600/NatDNADay.PNG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEhIeVl-LgGvBuFPFtI7LYCBLu7XrIUvMD-tLvqQVDLmWUmHEJmcpaeX14HMrXNvAeAek2h6QaZjK1ERezrUqMaeIdGBb9XjIQ-eCcRjTJC6OzkxpIzYQ2zIVZ3_pnPwrhh5HlrTWw/s320/NatDNADay.PNG" width="303" height="320" data-original-width="104" data-original-height="110" /></a></div><br />
Check the following sites for the details:<br />
<br />
<b>Genetic Genealogy</b>:<br />
<ul><li><a href="https://www.ancestry.com/dna/">AncestryDNA</a> Ancestry and Health.<br />
<li><a href="https://www.familytreedna.com/">Family Tree DNA</a> Separate tests for Ancestry, and Paternal or Maternal lines. Ends 26 April 2020.<br />
<li><a href="https://livingdna.com/blog/dna-day-2020">LivingDNA</a> Ancestry.<br />
<li><a href="https://www.myheritage.com/dna">MyHeritage</a> Ancestry. Ends 30 April 2020.<br />
<li><a href="https://www.23andme.com/">23andMe</a> Ancestry. Ends 26 April 2020.<br />
</ul><b>Whole Genome Sequencing</b> (Mainly for health and science. Not yet useful for genetic genealogy): <ul><li><a href="https://nebula.org/whole-genome-sequencing/">Nebula Genomics</a><br />
<li><a href="https://us.dantelabs.com/">Dante Labs</a> Ends 27 April 2020.<br />
<li><a href="https://www.fullgenomes.com/">Full Genomes</a>Different coverage levels for WGS, also Y DNA tests.<br />
</ul><br />
I have tested with all of these companies.<br />
Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-4339460417888270722020-04-04T17:20:00.000-05:002020-04-04T17:20:36.793-05:00Ken Burns', The Gene, on PBS, April 7th and 14th Premieres Tuesdays, April 7 & 14, 2020 8/7c<br />
<br />
<p><blockquote><b><a href="https://www.pbs.org/kenburns/the-gene/">The Gene: An Intimate History</a></b> weaves together science, history & personal stories for a historical biography of the human genome, while also exploring breakthroughs for diagnosis & treatment of genetic diseases & the complex ethical questions they raise.</blockquote></p><br />
<p>This is an adaptation of Siddhartha Mukherjee's book, <a href="https://www.amazon.com/dp/147673352X">The Gene: An Intimate History</a>, in 2 two hour long presentations. It is well worth the time for a genetic genealogist to view.</p>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-49002757773925482812020-03-14T17:28:00.000-05:002020-03-14T17:28:19.965-05:00My atDNA matches as of 14 March 2020:<table> <tr>
<th>Company</th>
<th>Matches</th>
</tr>
<tr>
<td>AncestryDNA</td>
<td>168,618</td></tr>
<tr><td>MyHeritage</td>
<td>118,821</td>
</tr>
<tr>
<td>FTDNA</td>
<td>8,597</td>
</tr>
<tr>
<td>23andme v2</td>
<td>2,674</td>
</tr>
<tr>
<td>23andMe v3</td>
<td>2,491</td>
</tr>
<tr>
<td>LivingDNA</td>
<td>10 </td></tr>
</table>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-36741427970534621322020-01-07T06:57:00.002-06:002020-01-07T06:57:37.580-06:00My Heritage 2019 event reviewSeveral of the genetic DNA companies are posting reviews of their activities in 2019. Here is one for MyHeritage:<br />
<br />
<a href="https://blog.myheritage.com/2019/12/wrapping-up-a-fantastic-2019/"><b>Wrapping Up a Fantastic-2019</b></a><br />
<br />
<p>MyHeritage is one of the companies I use for my own DNA research. It is the only site where I find information on my Spanish relatives. I encourage anyone with European ancestors to the USA within the past 150 years to test there as well as with the other companies.</p>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-81109060369254090932019-12-24T11:53:00.002-06:002019-12-24T11:53:42.888-06:00DNA test discounts are ending starting today!If you want to order a genealogy or health DNA test you should look at the main test sites today.<br />
<br />
<ul><li><a href="https://www.23andme.com/?slideout=true&vip=true">23andMe</a>: Ancestry and Ancestry and Health.<br />
<li><a href="https://www.ancestry.com/">Ancestry</a><br />
<li><a href="https://www.familytreedna.com/">FamilyTreeDna</a><br />
<li><a href="https://livingdna.com/">LivingDNA</a><br />
<li><a href="https://www.myheritage.com/dna">MyHeritage</a>: Ancestry and Ancestry and Health.<br />
</ul><br />
For the health tests, some USA states and other countries are excluded. Check the web sites if interested.<br />
<br />
Ancestry has sites in the UK, Australia, and Canada, as well as the USA.<br />
<br />
Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-50259955752551288122019-12-10T07:28:00.002-06:002019-12-10T07:28:32.701-06:00Verogen, a forensics company, has acquired GEDMATCHThe press release from Verogen is here: <a href="https://verogen.com/gedmatch-partners-with-genomics-firm/">GEDmatch Partners with Genomics Firm</a><br />
<br />
See, Debbie Kennet's post <a href="https://cruwys.blogspot.com/2019/12/gedmatch-has-been-acquired-by-forensic.html">https://cruwys.blogspot.com/2019/12/gedmatch-has-been-acquired-by-forensic.html</a> <br />
and Roberta Estes' post <a href="https://dna-explained.com/2019/12/10/gedmatch-acquired-by-verogen/">https://dna-explained.com/2019/12/10/gedmatch-acquired-by-verogen/</a><br />
<br />
Gedmatch members should receive an email about the changes.Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-20923148914828694452019-08-02T07:45:00.000-05:002019-08-02T07:45:39.122-05:00The Genetic History of France<h>The Genetic History of France</h><br />
<br />
<p>Aude SAINT PIERRE, Joanna Giemza, Mathilde Karakachoff, Isabel Alves, Philippe Amouyel, Jean-Francois Dartigues, Christophe Tzourio, Martial Monteil, Pilar Galan, Serge Hercberg, Richard Redon, Emmanuelle Genin, Christian Dina</p><br><br />
doi: https://doi.org/10.1101/712497<br />
<br><br />
<p>Full paper and supplementary info at<br><br />
<a href="https://www.biorxiv.org/content/10.1101/712497v2">https://www.biorxiv.org/content/10.1101/712497v2</a><br />
<br />
<p>This article is a preprint and has not been peer-reviewed</p><br />
<blockquote>Abstract<br />
<br />
The study of the genetic structure of different countries within Europe has provided significant insights into their demographic history and their actual stratification. Although France occupies a particular location at the end of the European peninsula and at the crossroads of migration routes, few population genetic studies have been conducted so far with genome-wide data. In this study, we analyzed SNP-chip genetic data from 2184 individuals born in France who were enrolled in two independent population cohorts.<br />
<br />
Using FineStructure, six different genetic clusters of individuals were found that were very consistent between the two cohorts. These clusters match extremely well the geography and overlap with historical and linguistic divisions of France. By modeling the relationship between genetics and geography using EEMS software, we were able to detect gene flow barriers that are similar in the two cohorts and corresponds to major French rivers or mountains. Estimations of effective population sizes using IBDNe program also revealed very similar patterns in both cohorts with a rapid increase of effective population sizes over the last 150 generations similar to what was observed in other European countries. A marked bottleneck is also consistently seen in the two datasets starting in the fourteenth century when the Black Death raged in Europe.<br />
<br />
In conclusion, by performing the first exhaustive study of the genetic structure of France, we fill a gap in the genetic studies in Europe that would be useful to medical geneticists but also historians and archeologists.</blockquote>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-83332165612261561402019-06-15T16:41:00.000-05:002019-06-15T16:45:19.968-05:00Father's Day Sale Prices for Autosomal DNA tests<p>These prices are good to 17 June 2019:</p><br />
<ul><li><a href="https://www.23andme.com/">23andMe</a>: $99 or Ancestry and Health is $150 - ends 17 June;<br />
<li><a href="https://www.ancestry.com/">Ancestry</a>: $59 - ends 17 June;<br />
<li><a href="https://www.familytreedna.com/">FTDNA</a>: $59 - ends 17 June;<br />
<li><a href="https://livingdna.com/">LivingDNA</a>: $79 - ends 17 June;<br />
<li><a href="https://www.myheritage.com/">MyHeritage</a>: $69 - ends 17 June.<br />
</ul><p>In addition FTDNA has sales on Y DNA and mtDNA tests.</p><br />
<br />
Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-49504515675033746812019-06-12T06:48:00.000-05:002019-12-24T11:54:13.683-06:00Y DNA Test Sale at FTDNA through 17 June<div class="separator" style="clear: both; text-align: center;"><a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgb9G3AKyq0HlyGNiCUVUIKfc9ZxqTJe1ynYQbeSiRZVeIy3YGVQ-LtP4elY9dQZkWC5l_xy96WP3fDSdTLu02rCqSpHF5kzIHftyQcaAeJMtWSVf8X2RQaTPWFN8ZTiqPDM_NYAA/s1600/YDNA_FTDNA.PNG" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEgb9G3AKyq0HlyGNiCUVUIKfc9ZxqTJe1ynYQbeSiRZVeIy3YGVQ-LtP4elY9dQZkWC5l_xy96WP3fDSdTLu02rCqSpHF5kzIHftyQcaAeJMtWSVf8X2RQaTPWFN8ZTiqPDM_NYAA/s320/YDNA_FTDNA.PNG" width="193" height="320" data-original-width="526" data-original-height="870" /></a></div><br />
<center><a href="https://www.familytreedna.com/products"><b>FTDNA Y DNA Sale</b></a></center>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-27640335125076739182019-05-05T21:08:00.001-05:002019-05-05T21:08:53.805-05:00Mother's Day autosomal DNA test prices:<center><p><b>Mother's Day autosomal test prices:</b><br />
<br><br><br />
<br />
<a href="https://www.23andme.com/">23andme. $99. Also a $30 discount on the Health & Ancestry package.</a><br><br />
<a href="https://www.ancestry.com/">Ancestry. $59. Offer ends May 13.</a><br><br />
<a href="https://www.familytreedna.com/products">Family Tree DNA. $79.</a><br><br />
<a href="https://livingdna.com/">Living DNA, $79.</a><br><br />
<a href="https://www.myheritage.com/dna">MyHeritage. $69. Sales ends May 13.</a><br />
</p></center>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-73079234284661871722019-05-05T13:10:00.000-05:002019-05-05T13:10:17.044-05:00Irish DNA Atlas<p>The Irish DNA Atlas has been published to present the results of a study on DNA in Ireland.<br />
<br />
From Nature:<br />
<br />
Article | OPEN | Published: 08 December 2017<br />
<br />
<a href="https://www.nature.com/articles/s41598-017-17124-4"><b>The Irish DNA Atlas: Revealing Fine-Scale Population Structure and History within Ireland</a></b><br><br />
Edmund Gilbert, Seamus O’Reilly, Michael Merrigan, Darren McGettigan, Anne M. Molloy, Lawrence C. Brody, Walter Bodmer, Katarzyna Hutnik, Sean Ennis, Daniel J. Lawson, James F. Wilson & Gianpiero L. Cavalleri<br> <br />
Scientific Reports volume 7, Article number: 17199 (2017) | Download Citation<br><br />
<br />
<b>An Author Correction to this article was published on 03 May 2018<br><br />
This article has been updated</b><br><br />
<br />
Abstract<br><br />
<blockquote>The extent of population structure within Ireland is largely unknown, as is the impact of historical migrations. Here we illustrate fine-scale genetic structure across Ireland that follows geographic boundaries and present evidence of admixture events into Ireland. Utilising the ‘Irish DNA Atlas’, a cohort (n = 194) of Irish individuals with four generations of ancestry linked to specific regions in Ireland, in combination with 2,039 individuals from the Peoples of the British Isles dataset, we show that the Irish population can be divided in 10 distinct geographically stratified genetic clusters; seven of ‘Gaelic’ Irish ancestry, and three of shared Irish-British ancestry. In addition we observe a major genetic barrier to the north of Ireland in Ulster. Using a reference of 6,760 European individuals and two ancient Irish genomes, we demonstrate high levels of North-West French-like and West Norwegian-like ancestry within Ireland. We show that that our ‘Gaelic’ Irish clusters present homogenous levels of ancient Irish ancestries. We additionally detect admixture events that provide evidence of Norse-Viking gene flow into Ireland, and reflect the Ulster Plantations. Our work informs both on Irish history, as well as the study of Mendelian and complex disease genetics involving populations of Irish ancestry. </blockquote><br />
See the article for discussion and maps.<br />
<br />
Also, see, <a href="https://www.nature.com/articles/ejhg2011127"><b>People of the British Isles: preliminary analysis of genotypes and surnames in a UK-control population</b></a><br />
</p>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-10835031872349764832019-05-05T12:41:00.000-05:002019-05-05T13:10:41.217-05:00April 2019 update from Living DNA<p>Living DNA is a DNA ancestry service from England. Originally it specialized in providing a geographic breakdown of your DNA to locations in England, Wales, Scotland, and Northern Ireland. It has added Eire and is going to be adding Germany to its reports. A news update is available at this link,<br />
<br />
<a href="https://livingdna.com/news/living-dna-april-2019-product-update">https://<b>livingdna.com/news/living-dna-april-2019-product-update</b></a> </p><br />
<br />
<br />
Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-4966794132804474712019-05-01T11:02:00.001-05:002019-05-01T11:02:08.269-05:00Genomic data and the GDPRFrom the PHG Foundation:<br />
<br />
<blockquote>The potential of technologies such as these, together with other digital technologies to fall outside existing regulatory frameworks has prompted radical reform of data protection law across Europe. Thus, in May 2018 the EU General Data Protection Regulation (GDPR) came into force across the continent and in the UK, further national legislation has been implemented through the UK’s Data Protection Act 2018. This legal framework governs of the use of personal data in healthcare and research, and it explicitly recognises the category of genetic data for the first time (it will continue to apply in the UK regardless of Brexit).<br />
<br />
However many, including Secretary of State for Health and Social Care, Matt Hancock, are concerned that the rules governing the use of genetic data could hinder the legitimate use of data for healthcare and research.<br />
</blockquote><br />
<b><a href="http://www.phgfoundation.org/blog/how-does-the-gdpr-apply-to-genomic-data">http://www.phgfoundation.org/blog/how-does-the-gdpr-apply-to-genomic-data</a></b><br />
<br />
<br />
<br />
<br />
Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-90273477186463500812019-01-01T01:28:00.000-06:002019-01-01T01:28:06.093-06:00Ancient nuclear genomes enable repatriation of Indigenous human remainshttp://advances.sciencemag.org/content/4/12/eaau5064<br />
<br />
Abstract<br />
<br />
After European colonization, the ancestral remains of Indigenous people were often collected for scientific research or display in museum collections. For many decades, Indigenous people, including Native Americans and Aboriginal Australians, have fought for their return. However, many of these remains have no recorded provenance, making their repatriation very difficult or impossible. To determine whether DNA-based methods could resolve this important problem, we sequenced 10 nuclear genomes and 27 mitogenomes from ancient pre-European Aboriginal Australians (up to 1540 years before the present) of known provenance and compared them to 100 high-coverage contemporary Aboriginal Australian genomes, also of known provenance. <br />
<br />
We report substantial ancient population structure showing strong genetic affinities between ancient and contemporary Aboriginal Australian individuals from the same geographic location. Our findings demonstrate the feasibility of successfully identifying the origins of unprovenanced ancestral remains using genomic methods.<br />
<br />
Article continues <a href="http://advances.sciencemag.org/content/4/12/eaau5064">http://advances.sciencemag.org/content/4/12/eaau5064</a>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-16689542296733548332018-12-25T09:13:00.001-06:002018-12-25T09:13:33.833-06:00Y Chromosome Sequences Reveal a Short Beringian Standstill, Rapid Expansion, and early Population structure of Native American Founders<a href="https://www.sciencedirect.com/science/article/pii/S0960982218314957"><b>https://www.sciencedirect.com/science/article/pii/S0960982218314957</b></a><br />
<br />
<p>Pinotti, T., Bergström, A., Geppert, M., Bawn, M., Ohasi, D., Shi, W., Lacerda, D.R., Solli, A., Norstedt, J., Reed, K. and Dawtry, K., 2018.</p><p>Current Biology.</p><br />
<p>The Americas were the last inhabitable continents to be occupied by humans, with a growing multidisciplinary consensus for entry 15–25 thousand years ago (kya) from northeast Asia via the former Beringia land bridge [1, 2, 3, 4]. Autosomal DNA analyses have dated the separation of Native American ancestors from the Asian gene pool to 23 kya or later [5, 6] and mtDNA analyses to ∼25 kya [7], followed by isolation (“Beringian Standstill” [8, 9]) for 2..4–9 ky and then a rapid expansion throughout the Americas. Here, we present a calibrated sequence-based analysis of 222 Native American and relevant Eurasian Y chromosomes (24 new) from haplogroups Q and C [10], with four major conclusions.</p><ul><li>First, we identify three to four independent lineages as autochthonous and likely founders: the major Q-M3 and rarer Q-CTS1780 present throughout the Americas, the very rare C3-MPB373 in South America, and possibly the C3-P39/Z30536 in North America. <br />
<li>Second, from the divergence times and Eurasian/American distribution of lineages, we estimate a Beringian Standstill duration of 2.7 ky or 4.6 ky, according to alternative models, and entry south of the ice sheet after 19.5 kya. <br />
<li>Third, we describe the star-like expansion of Q-M848 (within Q-M3) starting at 15 kya [11] in the Americas, followed by establishment of substantial spatial structure in South America by 12 kya. <br />
<li>Fourth, the deep branches of the Q-CTS1780 lineage present at low frequencies throughout the Americas today [12] may reflect a separate out-of-Beringia dispersal after the melting of the glaciers at the end of the Pleistocene.<br />
</ul><br />
Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-61028311643872745222018-11-23T10:14:00.004-06:002018-11-23T17:30:00.225-06:00Black Friday DNA test deals<p>The following companies are offering reduced cost autosomal DNA tests. These tests can be used to reliably find immediate family and cousins out to 4th or 5th cousins. Less reliably, they can give you ethnic ancestry results.</p><br />
<ul><li><a href="https://www.myheritage.com/">MyHeritage DNA</a> - $49 plus free shipping with coupon code Free18 (ends Nov 23)<br />
<li><a href="https://www.23andme.com/">23andMe</a> - $69 per kit, shipping extra, or $129 for the Ancestry + Health version (ends Nov 25)<br />
<li><a href="https://www.ancestry.com/dna/">AncestryDNA </a>- $49 per kit, plus shipping (ends Nov 26)<br />
<li>Family Tree DNA - $39 per DNA test, shipping extra (ends Nov 26)<br />
<li>LivingDNA through <a href="https://www.findmypast.co.uk/">Findmypast</a>, $59 plus shipping (ends Nov 26)<br />
<li><a href="https://livingdna.com/">LivingDNA</a> direct - $69 per kit, plus shipping (no posted end date)<br />
</ul><p>I have tested at all of these companies. <p>I recommend the following testing strategy:<br>
Test at <a href="https://www.ancestry.com/dna/">AncestryDNA</a> and <a href="https://www.23andme.com/">23andMe</a> and then upload the raw data to the others. This is the lowest cost strategy and gets your results into the largest commercial genetic genealogy databases. <p>An additional upload is to <a href="https://www.gedmatch.com/">Gedmatch</a>. This will allow people who have tested at only one company to match other people from different companies. Gedmatch has both free and fee services. The free services get you their matching service. <p>There is a new company <a href="https://us.dantelabs.com/">Dante Labs</a>, doing whole genome testing for $199.00 (L169.00) for Black Friday Week. This is a 30x coverage of your whole genome and can be used for learning about medical propensities. Not really useful for genealogy. <p>If you already have a test result, be sure to upload to MyHeritage and Living DNA before 1 December to avoid their new fee schedule. <p>If you are interested in graphical representation of your relative network, <a href="https://www.rootsfinder.com/">Rootsfinder</a> is another company to join before 1 December. <p><b>NOTE: I do not earn any money from your using any of these links. </b>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-70480699990939763062018-09-13T07:08:00.001-05:002018-09-13T07:09:47.869-05:00<br />
<a href="https://www.myheritage.com/"><b>MyHeritage</b></a> now supports the upload of 23andMe v5 and Living DNA data files, in addition to supporting data uploads from all major DNA testing services, including Ancestry, 23andMe (prior to V5) and Family Tree DNA (Family Finder).<br />
<br />
<blockquote>Since 2016, MyHeritage has allowed users who have already tested their DNA to upload their DNA data from Ancestry, 23andMe and Family Tree DNA. They receive DNA Matches and ethnicity estimates on MyHeritage for free.<br />
<br />
However, previously MyHeritage did not support the upload of tests based on the chip called GSA (Global Screening Array), now being used by 23andMe (v5), and by Living DNA. Recent improvements to their DNA algorithms now allows them to support DNA data processed on GSA chips, and so they now support uploads of 23andMe v5 and Living DNA data files.<br />
<br />
Uploading DNA data to MyHeritage is fast and simple -- perhaps one of the easiest. For users that upload now, they offer full access to DNA Matching, Ethnicity Estimates, and their chromosome browser for free.<br />
<br />
Upload your Ancestry, FamilyTreeDNA, 23andMe, and LivingDNA to MyHeritage <a href="https://www.myheritage.com/dna/upload"><b>here</b></a>.<br />
<br />
Incentive to upload before December 1<br />
If you have not uploaded your DNA raw data to MyHeritage, you should think about doing so now.<br />
<br />
As of December 1, 2018, MyHeritage's policy regarding DNA uploads will change: DNA Matching will remain free for uploaded DNA data, but unlocking additional DNA features (for example, ethnicity estimate, chromosome browser, and some others) will require an extra payment for DNA files uploaded after this date.<br />
<br />
MyHeritage will announce the full details of the new policy once it is finalized, closer to December 1.<br />
<br />
All DNA data that was uploaded to MyHeritage in the past, and all DNA data that is uploaded now and prior to December 1, 2018, will continue to enjoy full access to all DNA features for free. These uploads will be grandfathered in and will remain free.</blockquote>Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0tag:blogger.com,1999:blog-6960503.post-87681112479921300042018-08-09T06:48:00.001-05:002018-08-09T06:51:55.501-05:00Last day (9 August) for sale prices on 23andMe Ancestry and Health DNA tests! Offer ends today, 9 August 2018: <a href="https://www.23andme.com/"><b>23andMe sale</b></a>. Also being offered on Amazon.<br />
<br />
NOT an Affiliate link.Steven C Perkinshttp://www.blogger.com/profile/03578164804219522899noreply@blogger.com0