Review Article
Ancestry and Disease in the Age of Genomic Medicine
http://www.nejm.org/doi/full/10.1056/NEJMra0911564?query=TOC#t=articleTop
W. Gregory Feero, M.D., Ph.D., Editor, Alan E. Guttmacher, M.D., Editor
Ancestry and Disease in the Age of Genomic Medicine
Charles N. Rotimi, Ph.D., and Lynn B. Jorde, Ph.D.
N Engl J Med 2010; 363:1551-1558 October 14, 2010
Human genetic data are accumulating at an ever-increasing pace, and whole genome sequences of individuals from multiple populations are now publicly available.1-3 The growing inventory of human genetic variation is facilitating an understanding of why susceptibility to common diseases varies among individuals and populations. In addition, we are gaining insights that may improve the efficacy and safety of therapeutic drugs. Such knowledge is relevant to fundamental questions about our origins, differences, and similarities. Here, we provide a brief review of the current knowledge of human genetic variation and how it contributes to our understanding of human evolutionary history, group identity, and health disparities.
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