Saturday, January 29, 2011

My new 23andMe matches since version 3 results have started coming in

Late Tuesday I had 594 matches in Relative Finder at 23andMe. On Wednesday I had 624, and on Thursday I had 655. Friday I added 2 more and 2 more again today, Saturday, 29 January, for a total of 659. Only one match has been at the 3rd cousin level. The rest have been in the 4th to 5th cousin range with a few "Distant Cousins" thrown in. One person had 5 links to me and one person had a single 50cm link. So far 3 people have accepted contact and shared genomes.

I'll post periodic updates as more matches come in.

Tuesday, January 25, 2011

Comparison of Verison 3 results to Version 2 at 23andme

CeCe Moore has reported on her quick comparison of her version 3 results to her version 2 results from 23andMe. According to an analysis by Jim McMillan there are approximately 30K SNPs that were in version 2 that are not in version 3.

Here is the link:Update on 23andMe's v3 results: Relative Finder comparison and ~30,000 v2 locations missing from v3

Saturday, January 22, 2011

Combining document genealogy with genetic genealogy: "The man who wasn't John CharlesBrown "

One of the goals of this site is to show how to use genetic genealogy to assist with document genealogy. Randy Majors has a recent post that does just that. Read it on his website: The man who wasn't John Charles Brown

Wednesday, January 19, 2011

We may have more in common with friends than we think we do:

Correlated genotypes in friendship networks

Full text:

    James H. Fowlera,b,1,
    Jaime E. Settleb, and
    Nicholas A. Christakisc,d

+ Author Affiliations

    aDivision of Medical Genetics,
    bDepartment of Political Science, University of 
California at San Diego, La Jolla, CA 92093;
    cDepartment of Medicine and Department of Health 
Care Policy, Harvard Medical School, Boston, MA 02115; 
    dDepartment of Sociology, Faculty of Arts and 
Sciences, Harvard University, Cambridge, MA 02138

    Edited by Gene E. Robinson, University of Illinois, 
Urbana, IL, and approved December 15, 2010 
(received for review August 6, 2010)

It is well known that humans tend to associate with other humans who have similar characteristics, but it is unclear whether this tendency has consequences for the distribution of genotypes in a population. Although geneticists have shown that populations tend to stratify genetically, this process results from geographic sorting or assortative mating, and it is unknown whether genotypes may be correlated as a consequence of nonreproductive associations or other processes. Here, we study six available genotypes from the National Longitudinal Study of Adolescent Health to test for genetic similarity between friends. Maps of the friendship networks show clustering of genotypes and, after we apply strict controls for population stratification, the results show that one genotype is positively correlated (homophily) and one genotype is negatively correlated (heterophily). A replication study in an independent sample from the Framingham Heart Study verifies that DRD2 exhibits significant homophily and that CYP2A6 exhibits significant heterophily. These unique results show that homophily and heterophily obtain on a genetic (indeed, an allelic) level, which has implications for the study of population genetics and social behavior. In particular, the results suggest that association tests should include friends’ genes and that theories of evolution should take into account the fact that humans might, in some sense, be metagenomic with respect to the humans around them.


    1To whom correspondence should be addressed. E-mail:
    Author contributions: J.H.F., J.E.S., and N.A.C. 
designed research, performed research, analyzed data, 
and wrote the paper.
    The authors declare no conflict of interest.
    This article is a PNAS Direct Submission.
    This article contains supporting information online at

Freely available online through the PNAS open access option.

See this comment at Genetic Future by Daniel McArthur: