Palatines to America Fall Conference - Genetic Genealogy Presentations

Title: New Holland, PA - Genetic Genealogy Presentations

Date:   Saturday October 13, 2007 
Time:   9:30 am - 3:30 pm  
Location:   Yoder's Meeting Rooms 
City State Zip:   New Holland, PA  
Notes:   "Genetic Genealogy: An Introduction"
"The Kerchner Surname Project"
"Y-DNA Projects in Genealogy"
"mtDNA Projects in Genealogy"
Speakers: Charles F. Kerchner, 
Steven Perkins, and Bill Hurst
Palatines to America Fall Conference - PA Chapter
http://www.pa-palam.org/index_files/page0001.htm
$35 Registration Fee - includes lunch 

4th International Conference on Genetic Genealogy for Family Tree DNA Group Administrators

HOUSTON, July 5, 2007 (For Immediate Release) – Family Tree DNA, the world leader in the field of genetic genealogy, is pleased to announce its 4th International Conference on Genetic Genealogy for Group Administrators. The event will take place on October 20-21, 2007 at the Houston Marriott West Loop in Houston, TX. The two-day conference features leading experts exploring a variety of topics related to using DNA for family history and deep ancestral origins.

The conference is open to genealogists from all over the world who currently manage Group Projects at Family Tree DNA and want to learn more about how to make the most of DNA testing for genealogy by having a better understanding of the science, and the impact it has on family studies and traditional genealogy.

Continued at http://www.ftdna.com/conference_pr07.html

Dr. Henry Louis Gates, Jr. will be a speaker on the first day of the conference. The program is listed at http://www.ftdna.com/conference_2007_reg.asp

Seeking Columbus's Origins with a swab

By AMY HARMON
Published: October 8, 2007

"BARCELONA, Spain — When schoolchildren turn to the chapter on Christopher Columbus’s humble origins as the son of a weaver in Genoa, they are not generally told that he might instead have been born out of wedlock to a Portuguese prince. Or that he might have been a Jew whose parents converted to escape the Spanish Inquisition. Or a rebel in the medieval kingdom of Catalonia."

Continued at New York Times: http://www.nytimes.com/2007/10/08/us/08columbus.html

Personal Genomics and the End of Insurance

From Venture Beat:

Personal genomics and the end of insurance
By David P. Hamilton 09.11.07

"Not too long from now, your genes are likely to be at war with your health insurer — and your genes may well have the upper hand.

Within the next few years, it should become fairly easy and inexpensive to get a rough-and-ready readout of your own genetic code, one that you can scan for information on which diseases you’re most likely to contract, which drugs will help you the most, and ultimately even how your children might turn out. In other words, a brave new world of genetic transparency is on its way, one that promises to empower individuals to an extent that’s still difficult to grasp. (For some preliminary thoughts on that subject, see here, here and here.)"

Continued at http://venturebeat.com/2007/09/11/personal-genomics-and-the-end-of-insurance

Dr J Craig Venter has released his full genome

The Diploid Genome Sequence of an Individual Human

Samuel Levy1*, Granger Sutton1, Pauline C. Ng1, Lars Feuk2, Aaron L. Halpern1, Brian P. Walenz1, Nelson Axelrod1, Jiaqi Huang1, Ewen F. Kirkness1, Gennady Denisov1, Yuan Lin1, Jeffrey R. MacDonald2, Andy Wing Chun Pang2, Mary Shago2, Timothy B. Stockwell1, Alexia Tsiamouri1, Vineet Bafna3, Vikas Bansal3, Saul A. Kravitz1, Dana A. Busam1, Karen Y. Beeson1, Tina C. McIntosh1, Karin A. Remington1, Josep F. Abril4, John Gill1, Jon Borman1, Yu-Hui Rogers1, Marvin E. Frazier1, Stephen W. Scherer2, Robert L. Strausberg1, J. Craig Venter1

1 J. Craig Venter Institute, Rockville, Maryland, United States of America,
2 Program in Genetics and Genomic Biology, The Hospital for Sick Children, and Molecular and Medical Genetics, University of Toronto, Toronto, Ontario, Canada,
3 Department of Computer Science and Engineering, University of California San Diego, La Jolla, California, United States of America,
4 Genetics Department, Facultat de Biologia, Universitat de Barcelona, Barcelona, Catalonia, Spain

Presented here is a genome sequence of an individual human. It was produced from 32 million random DNA fragments, sequenced by Sanger dideoxy technology and assembled into 4,528 scaffolds, comprising 2,810 million bases (Mb) of contiguous sequence with approximately 7.5-fold coverage for any given region. We developed a modified version of the Celera assembler to facilitate the identification and comparison of alternate alleles within this individual diploid genome. Comparison of this genome and the National Center for Biotechnology Information human reference assembly revealed more than 4.1 million DNA variants, encompassing 12.3 Mb. These variants (of which 1,288,319 were novel) included 3,213,401 single nucleotide polymorphisms (SNPs), 53,823 block substitutions (2–206 bp), 292,102 heterozygous insertion/deletion events (indels)(1–571 bp), 559,473 homozygous indels (1–82,711 bp), 90 inversions, as well as numerous segmental duplications and copy number variation regions. Non-SNP DNA variation accounts for 22% of all events identified in the donor, however they involve 74% of all variant bases. This suggests an important role for non-SNP genetic alterations in defining the diploid genome structure. Moreover, 44% of genes were heterozygous for one or more variants. Using a novel haplotype assembly strategy, we were able to span 1.5 Gb of genome sequence in segments >200 kb, providing further precision to the diploid nature of the genome. These data depict a definitive molecular portrait of a diploid human genome that provides a starting point for future genome comparisons and enables an era of individualized genomic information.

Funding. Funding was provided from the J. Craig Venter Institute, Genome Canada/Ontario Genomics Institute, The Hospital for Sick Children Foundation, the McLaughlin Centre for Molecular Medicine, and the Canada Foundation for Innovation. SWS is an Investigator of the Canadian Institutes of Health Research (CIHR) and a Fellow of the Canadian Institute for Advanced Research. LF is supported by CIHR scholarship.

Competing interests. The authors have declared that no competing interests exist.

Academic Editor: Edward M. Rubin, Lawrence Berkeley National Laboratories, United States of America

Citation: Levy S, Sutton G, Ng PC, Feuk L, Halpern AL, et al. (2007) The Diploid Genome Sequence of an Individual Human. PLoS Biol 5(10): e254 doi:10.1371/journal.pbio.0050254

Received: May 9, 2007; Accepted: July 30, 2007; Published: September 4, 2007

Off the Beaten Path: An Interview with Spencer Wells

From PLoS:
Jane Gitschier
Citation: Gitschier J (2007) Off the Beaten Path: An Interview with Spencer Wells. PLoS Genet 3(3): e44 doi:10.1371/journal.pgen.0030044

"Spencer Wells has this geneticist's dream job. He transits the globe, collecting DNA samples, building collaborations, and orchestrating what may be the most extensive and fascinating project on human origins yet, sponsored by one of the most respected institutions in the US—The National Geographic Society. There, Wells holds the oxymoronically named post of “Explorer-in-Residence” and runs the Genographic Project (http://www.nationalgeographic.com/genographic), whose mission is to collect and genotype the Y and mitochondrial chromosomes from people the world over in order to track male and female lineages, respectively, and thereby infer migratory patterns throughout human history.

I was curious to learn how someone so young (he started working with National Geographic when he was only 33) could plunge into a project of this magnitude. The answer is that Wells is a man of many facets, vision, and energy. And he has a knack for creating the opportunity."

Continued here:
http://genetics.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pgen.0030044&ct=1

African American Lives 2

NEW YORK -- In February 2006, the acclaimed PBS series African American Lives brought to the forefront of national consciousness the powerful process of discovering one’s family history. A Roots for the 21st century, the series made a deep cultural impact through its riveting use of DNA analysis, genealogical research and family oral tradition to trace the lineages of highly accomplished African Americans down through U.S. history and back to Africa.

One year later, Oprah’s Roots further crystallized and propelled America’s interest in family tree research through the powerful stories of Oprah Winfrey’s ancestors and their accomplishments.

Now, you too are invited to participate in the newest African American Lives project. The producers of African American Lives 2 are seeking an African American to join Harvard professor Henry Louis Gates Jr. and an all-new group of distinguished African Americans on an extraordinary journey of discovery. The series is tentatively scheduled to air on PBS in February 2008.

"What we find in doing this research is that even a regular person has extraordinary stories within his or her family," says Professor Gates. "In African American Lives 2, we’ll work with one such person to show that the technology and resources for discovering these stories are available to all Americans, especially those of African descent."

Under the supervision of Professor Gates, the series’ research will be conducted by the eminent genealogists Tony Burroughs, Johni Cerny, Jane Ailes and Megan Smolenyak together with Ancestry.com, one of the world’s leading online resources for family history information. They’ll research the selected individual’s family history, while a DNA testing service will provide a genetic analysis. The results of both will be revealed, along with that of the other series participants, by Professor Gates on the PBS broadcast of African American Lives 2.

HOW TO ENTER

Beginning April 18th, interested individuals must apply online at www.pbs.org/aalives. Online applications must be received by 6:00 p.m. on Friday, May 4, 2007. Any applications submitted after this date and time will not be considered. Finalists will receive a one-year subscription to Ancestry.com. The winning applicant will be notified and announced the week of May 28, 2007. Please note that the following are not eligible to participate: employees, and their relatives, of PBS, the series’ producers (Thirteen/WNET, Kunhardt Productions, and Inkwell Films) and corporate sponsors (The Coca-Cola Company, Johnson & Johnson and General Motors).

In addition to their name, age, gender, and contact information, applicants will be asked to tell the judges about themselves and their family, and why they would make the ideal candidate for the series.

Upon submitting the online application, individuals will receive an e-mail confirmation with a unique identification number. Applicants must attach this number along with their name to a photograph of themselves and mail it to: African American Lives 2, 305 West Broadway, Suite 144, New York, NY 10013. Photographs must be postmarked no later than Monday, May 7. Applications are not complete until the production team receives an individual’s photograph.

Major corporate funding for African American Lives 2 is provided by The Coca-Cola Company and Johnson & Johnson. Additional funding is provided by General Motors.

African American Lives 2 is a co-production of Thirteen/WNET New York, Kunhardt Productions and Inkwell Films. Graham Judd is series producer; Dyllan McGee is senior producer for Kunhardt Productions. Executive producers are Henry Louis Gates Jr., William R. Grant and Peter W. Kunhardt.

Neanderthal DNA Center at Nature

Nature magazine has created a Neanderthal DNA center on their website at this location: http://www.nature.com/nature/focus/neanderthaldna/index.html.

Most of the material is freely accessible.

New DNA Test Is Yielding Clues to Neanderthals

SCIENCE | November 16, 2006
New DNA Test Is Yielding Clues to Neanderthals
By NICHOLAS WADE

The archaic human species that dominated Europe until 30,000 years ago is about to emerge from the shadows. With the help of a new DNA sequencing machine that operates with firefly light, the bones of the Neanderthals have begun to tell their story to geneticists.

One million units of Neanderthal DNA have already been analyzed, and a draft version of the entire genome, 3.2 billion units in length, should be ready in two years, said Dr. Svante Paabo, the leader of the research project at the Max Planck Institute for Evolutionary Anthropology in Leipzig, Germany.

Continued, (may require login) here

Legendary pilot 'Earthquake McGoon' heads home

From CNN:
Legendary pilot 'Earthquake McGoon' heads home POSTED: 7:29 p.m. EDT, October 19, 2006

NEW YORK (AP) -- More than a half century after he died in the flaming crash of a CIA-owned cargo plane and became one of the first two Americans to die in combat in Vietnam, a legendary soldier of fortune known as "Earthquake McGoon" is coming home.

The skeletal remains of James B. McGovern Jr., discovered in an unmarked grave in remote northern Laos in 2002, were positively identified on September 11 by laboratory experts at the U.S. military's Joint POW/MIA Accounting Command in Hawaii.

They will be flown back to the mainland next week for a military funeral in New Jersey on October 28, said McGovern's nephew, James McGovern III, of Forked River, New Jersey.

"Bottom line, it's closure for my family and a great feeling," McGovern said.

Continued at
http://www.cnn.com/2006/US/10/19/earthquake.mcgoon.ap/index.html